7:00 – 8:00 AM: Registration, Coffee & Breakfast
Setting the Stage: Where Have We Been, Where Are We Now, Where Are We Headed
Chairs: Nathan Bryan and Martin Feelisch
8:00 – 8:30 AM Nathan Bryan – Welcome, Introduction, Meeting Expectations
8:30 – 9:15 AM Lou Ignarro – Nobel Prize Discoveries
9:15 – 10:00 AM Jonathan Stamler – General Overview of the NO Field (SWOT Analysis)
10:00 – 10:45 AM Martin Feelisch – Nitric Oxide: Where Does it Go, What Does it Become and How Does it Signal?
10:45 – 11:15 AM Coffee Break & Exhibitors
Nitric Oxide Production Pathways
Chairs: Dennis Stuehr, Ph.D.; Amrita Ahluwalia, Ph.D.
11:15 – 11:45 AM Dennis Stuehr – Nitric Oxide Synthase and sGC Activation
11:45 – 12:15 AM Jose Tanus-Santos – From Stomach to Vasculature: How Gastric S-Nitrosothiol Formation Shapes the Cardiovascular Actions of Oral Nitrite and Nitrate
12:15 – 1:45 PM Lunch & Networking
Cardiovascular Failure and NO Signaling
Chairs: Wally Koch, Ph.D.; Joseph Loscalzo, M.D.
1:45 – 2:00 PM Co-Chairs Introduction: Primer on Hypertension and Heart Failure
2:00 – 2:30 PM Joseph Loscalzo – Therapeutic Applications of Nitric Oxide in Cardiology
2:30 – 3:00 PM Wally Koch – Role of NO Signaling in Heart Failure
3:00 – 3:30 PM David Lefer – Nitric Oxide as a Treatment for Heart Failure
3:30 – 4:00 PM Kathy Maglioto – Plethysmography for Endothelial Dysfunction
4:00 – 4:30 PM Coffee & Exhibitors
4:30 – 5:15 PM Pankaj Arora – Inhaled NO in Cardiac Surgery
5:15 – 6:00 PM Amrita Ahluwalia – Inorganic Nitrate as a Treatment for Hypertension
6:00 – 6:30 PM Panel Discussion with Lou Ignarro
7:30 – 9:00 PM Dinner
Asthma, Infections and Respiratory Medicine
Chairs: Serpil Eruzum, M.D.; Mark Gladwin, M.D.
8:00 – 8:15 AM Co-Chairs Primer on Asthma and Respiratory Illness
8:15 – 9:00 AM Ben Gaston – GSNORi as a Therapeutic Target for Asthma
9:00 – 9:45 AM Mark Schoenfisch – NO as an Anti-Gram-Positive and Gram-Negative Agent
9:45 – 10:30 AM Lorenzo Berra – Inhaled Nitric Oxide and Respiratory Failure
10:30 – 11:00 AM Coffee Break & Exhibitors
Novel Therapies and Biomedical Engineering
Chairs: Lorenzo Berra, M.D., Jonathan Stamler, M.D.
11:00 – 11:30 AM Binglan Yu – Novel Indications and Delivery Devices for NO Therapy
11:30 – 12:00 PM TBD – NO and Wound Healing
12:00 – 1:30 PM Lunch & Networking
Nitric Oxide Biological Chemistry
Chairs: Dennis Stuehr, Ph.D.; Jack Lancaster, Ph.D..
1:30 – 1:45 PM Co-Chairs Introduction – Review of NO Regulation through Metalloproteins
1:45 – 2:15 PM Elizabeth Boon – HNOX Sensing in Bacteria
2:15 – 2:45 PM Doug Thomas – NO and Metals: Quorum Sensing in Bacteria
2:45 – 3:15 PM Nick LeBrun – NO Reaction with FeS Derepresses Genes Impacting Microbial Survival
3:15 – 3:45 PM Coffee Break & Exhibitors
3:45 – 4:15 PM Late breaking abstracts (5 min talks)
4:15 – 6:15 PM Posters and Happy Hour
6:15 – 7:00 PM Panel Discussion with Speakers
7:30 – 12:00 PM Dinner Banquet & Live Music Entertainment (Update on current Administration policy on research and funding – special guest invited.
NO Production and Signaling in Diabetes, Renal, and Metabolic Disease
Chairs: Nathan S. Bryan, Martin Feelisch
8:00 – 8:15 AM Primer on NO and Insulin Signaling
8:15 – 9:00 AM John Corbett – How Nitric oxide induces "metabolic suspended animation" to protect islets
9:00 – 9:45 AM Jimmy Chang – Nitric Oxide in Urea Cycle Disorders
9:45 – 10:30 AM Erika Palmieri – Nitric Oxide Rewiring of the Immunometabolic Niche
10:30 – 11:00 AM Coffee Break & Exhibition
Meet the Editors and Abstract Awards
11:00 – 12:00 PM Miriam Cortese Krott & Christopher G. Kevil – Editors for Nitric Oxide and Redox Biology (Joint Interactive Session)
12:00 – 12:30 PM Abstract Awards Ceremony
12:30 – 2:00 PM Lunch & Networking (1 h 30 min)
Cancer and Nitric Oxide
Chairs: David Wink, Ph.D.
2:00 – 2:30 PM Tim Billiar – NOS Inhibitors: Indication, Trial Design, Outcomes
2:30 – 3:00 PM David Wink – Nitric Oxide in Cancer
3:00 – 3:30 PM Giuseppe Filomeni, Ph.D. – The Role of SNO Signaling in Cancer
3:30 – 4:00 PM Coffee Break & Exhibitors
4:00 - 4:45 PM Jack Lancaster – Unresolved Questions in the NO Field
4:45 – 5:00 PM 2028 Meeting Announcement & Closing Remarks by Nathan Bryan
Evening: Explore Austin – Dinner on your own
Optional: Bus to Oasis on Lake Travis for Sunset
